"My advice is that you shouldn't make up your mind based exclusively on what you hear in advertising," says Bender, a psychologist who serves as an assembly chairman of the American Thoracic Society."The newer prescribed medications are very expensive, and until you try it, you don't really know whether an old-fashioned, 5- or 10-cent, first-generation capsule will take care of your symptoms without causing sedation." But others studies show a big difference -- including one trial conducted at the University of Iowa three years ago in which researchers gave patients simulated driving tests after administering either Allegra, Bendryl, a placebo, or enough alcohol to make the patient legally drunk." These newer products, which include Allegra, Zyrtec, and Claritin, generally cost between 10 to 20 times as much as the older, "first-generation" products.
So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.
Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications.
Alterations of the allergic rhinitis symptoms including rhinorrhea, sneezing, nasal itching and nasal obstruction were compared between the two groups.
Results: Severity of all four studied symptoms was reduced by both drugs. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM.
There are few direct comparator studies between these two drugs with inconsistent results. Zheng M, Wang X, Bo M, Wang K, Zhao Y, He F, et al. Bousquet J, van Cauwenberge P, Khaltaev N, ARIA Workshop Group, World Health Organization.
Materials and Methods: A randomized, double-blind study for comparison the therapeutic effects of Loratadine and Cetirizine was conducted in an otolaryngologic clinic of a general hospital. Selecting the optimal oral antihistamine for patients with allergic rhinitis. Prevalence of allergic rhinitis among adults in urban and rural areas of china: a population-based cross-sectional survey. That study was sponsored by the company that manufactures Allegra.Still, Cohen says what makes it important is that it had patients perform a technical skill that requires optimal alertness.To find the most current information, please enter your topic of interest into our search box." April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.Conclusion: Loratadine and Cetirizine can reduce symptoms of the perennialallergic rhinitis but their difference is not statistically significant. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history.