Trillo releases his self-titled debut album in 2007 under Indi Music.It was in the same year when he made his fourth Lenten drama special for GMA Network under APT Entertainment entitled Unico Hijo.
On August 21, 2007, he started taping for the fantasy series Zaido: Pulis Pangkalawakan with Aljur Abrenica and Marky Cielo.
The same year, Trillo joined the stellar cast of Magdusa Ka, an afternoon soap opera which later earned an International Emmy nomination the following year.
After playing the lead role in the Philippine adaptation of Temptation Of Wife, Trillo lead his most controversial role to date as Eric del Mundo in his second International Emmy nominee In 2014, he top-billed the Primetime drama series Hiram na Alaala with Kapuso actress Kris Bernal.
He also had a weekly medical drama with Bela Padilla entitled Sa Puso ni Dok under GMA News & Public Affairs department.
He appeared in Sine Novela Presents: Gumapang Ka Sa Lusak opposite Jennylyn Mercado and portrayed Andrew Tantoco in the Philippine adaptation of the hit Korean series Endless Love.
In 2011, Trillo appeared in the romantic-fantasy series Dwarfina where he teamed-up with Heart Evangelista.
Trillo was born to Florita Florencio Ho, a Filipino, and Abelardo Leslie Ho, a Chinese Filipino from Dumaguete, Negros Oriental on May 12, 1981 in Quezon City.
He finished high school at Jose Abad Santos Memorial School, Quezon City and spent his grade school years (grades 1–7) at the Ateneo De Manila University. He took part in ABS-CBN's hit television soap operas Pangako Sa 'Yo as Ruel and Sa Dulo Ng Walang Hanggan as Jojo, both were minor characters.
Following this recognition, he received five more Best Actor trophies from the Film Academy of the Philippines, the Filipino Academy of Movie Arts and Sciences (FAMAS), the PMPC Star Awards for Movies, Golden Screen Awards and the Young Critics Circle.
He was also included in the third installment of Mano Po.
La Luna Sangre is the third installment to Lobo, and Imortal, two series that revolve around the tales of wolves, vampires and humans.